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Standard fluoropyrimidine dosages in chemoradiation therapy result in an increased risk of severe toxicity in DPYD variant allele carriers.
Lunenburg, Carin A T C; Henricks, Linda M; Dreussi, Eva; Peters, Femke P; Fiocco, Marta; Meulendijks, Didier; Toffoli, Giuseppe; Guchelaar, Henk-Jan; Swen, Jesse J; Cecchin, Erika; Schellens, Jan H M; Gelderblom, Hans.
Afiliación
  • Lunenburg CATC; Department of Medical Oncology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Henricks LM; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Dreussi E; Experimental and Clinical Pharmacology Unit, National Cancer Institute, Aviano, Italy.
  • Peters FP; Department of Radiotherapy, Leiden University Medical Centre, Leiden, The Netherlands.
  • Fiocco M; Medical Statistics, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands; Mathematical Institute, Leiden University, The Netherlands.
  • Meulendijks D; Dutch Medicines Evaluation Board (CBG-MEB), Utrecht, The Netherlands.
  • Toffoli G; Experimental and Clinical Pharmacology Unit, National Cancer Institute, Aviano, Italy.
  • Guchelaar HJ; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Swen JJ; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Cecchin E; Experimental and Clinical Pharmacology Unit, National Cancer Institute, Aviano, Italy.
  • Schellens JHM; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Division of Pharmacoepidemiology & Clinical Pharmacology, Department of Pharmac
  • Gelderblom H; Department of Medical Oncology, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address: A.J.Gelderblom@lumc.nl.
Eur J Cancer ; 104: 210-218, 2018 11.
Article en En | MEDLINE | ID: mdl-30361102
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Dihidrouracilo Deshidrogenasa (NADP) / Deficiencia de Dihidropirimidina Deshidrogenasa / Quimioradioterapia / Capecitabina / Fluorouracilo / Enfermedades Gastrointestinales / Enfermedades Hematológicas / Proteínas de Neoplasias / Neoplasias / Antimetabolitos Antineoplásicos Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cancer Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Dihidrouracilo Deshidrogenasa (NADP) / Deficiencia de Dihidropirimidina Deshidrogenasa / Quimioradioterapia / Capecitabina / Fluorouracilo / Enfermedades Gastrointestinales / Enfermedades Hematológicas / Proteínas de Neoplasias / Neoplasias / Antimetabolitos Antineoplásicos Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cancer Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos