On association of the lethal yellow (AY) mutation in the agouti gene with the alterations in mouse brain and behavior.
Behav Brain Res
; 359: 446-456, 2019 02 01.
Article
en En
| MEDLINE
| ID: mdl-30447239
ABSTRACT
Lethal yellow (AY) mutation causes obesity and type-2 diabetes in mice. Here we studied the effect of the AY mutation on the brain and behavior. The experiments were carried out on adult (11-12 weeks old) males of AY/a mice and their wild-type littermates (a/a). Mice of AY/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. At the same time, the fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in AY/a mice compared with a/a ones. Magnetic resonance imaging revealed a significant reduction of cortex volume in AY/a mice. The level of mRNA of Ptpn5 gene encoding striatal enriched tyrosine phosphatase in the frontal cortex of AY/a mice was significantly elevated compared with their wild-type littermates. This is the first report on the alterations in the brain and behavior in the AY/a mouse line. It is tempting to speculate that this mouse line can serve as a new and useful preclinical model to study neurobehavioral complications associated with obesity and type-2 diabetes.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
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Encéfalo
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Proteína de Señalización Agouti
/
Mutación
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia