Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder.

Abdolmaleky, Hamid M; Gower, Adam C; Wong, Chen-Khuan; Cox, Jiayi W; Zhang, Xiaoling; Thiagalingam, Arunthathi; Shafa, Rahim; Sivaraman, Vadivelu; Zhou, Jin-Rong; Thiagalingam, Sam

Abdolmaleky, Hamid M; Gower, Adam C; Wong, Chen-Khuan; Cox, Jiayi W; Zhang, Xiaoling; Thiagalingam, Arunthathi; Shafa, Rahim; Sivaraman, Vadivelu; Zhou, Jin-Rong; Thiagalingam, Sam.

Afiliación

Abdolmaleky HM; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Gower AC; Nutrition/Metabolism Laboratory, BIDMC, Harvard Medical School, Boston, Massachusetts.
Wong CK; Clinical and Translational Science Institute, Boston University School of Medicine, Boston, Massachusetts.
Cox JW; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Zhang X; Genetics & Genomics Graduate Program, Boston University School of Medicine, Boston, Massachusetts.
Thiagalingam A; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Shafa R; Bioinformatics Graduate Program, Boston University, Boston, Massachusetts.
Sivaraman V; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Zhou JR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Thiagalingam S; Metrowest CNS Research Center, Natick, Massachusetts.

Am J Med Genet B Neuropsychiatr Genet ; 180(2): 138-149, 2019 03.

Article en En | MEDLINE | ID: mdl-30468562

Asunto(s)

Trastorno Bipolar/genética; Encéfalo/patología; Esquizofrenia/genética; Adulto; Autopsia; Metilación de ADN/genética; Epigénesis Genética/genética; Epigenoma/genética; Femenino; Predisposición Genética a la Enfermedad/genética; Humanos; Masculino; Persona de Mediana Edad; Regiones Promotoras Genéticas; Trastornos Psicóticos/genética; Transducción de Señal/genética; Transcriptoma/genética; Factor de Crecimiento Transformador beta/metabolismo; Secuenciación Completa del Genoma/métodos

Palabras clave

NR2E1; TGFB2; DNA methylation; brain asymmetry; schizophrenia

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar / Encéfalo Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Med Genet B Neuropsychiatr Genet Asunto de la revista: GENETICA MEDICA / NEUROLOGIA / PSIQUIATRIA Año: 2019 Tipo del documento: Article

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