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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.
Sliz, Eeva; Kettunen, Johannes; Holmes, Michael V; Williams, Clare Oliver; Boachie, Charles; Wang, Qin; Männikkö, Minna; Sebert, Sylvain; Walters, Robin; Lin, Kuang; Millwood, Iona Y; Clarke, Robert; Li, Liming; Rankin, Naomi; Welsh, Paul; Delles, Christian; Jukema, J Wouter; Trompet, Stella; Ford, Ian; Perola, Markus; Salomaa, Veikko; Järvelin, Marjo-Riitta; Chen, Zhengming; Lawlor, Debbie A; Ala-Korpela, Mika; Danesh, John; Davey Smith, George; Sattar, Naveed; Butterworth, Adam; Würtz, Peter.
Afiliación
  • Sliz E; Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  • Kettunen J; Biocenter Oulu, Oulu, Finland.
  • Holmes MV; Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  • Williams CO; Biocenter Oulu, Oulu, Finland.
  • Boachie C; Computational Medicine, Faculty of Medicine, University of Oulu, Finland.
  • Wang Q; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
  • Männikkö M; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Sebert S; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.
  • Walters R; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
  • Lin K; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Millwood IY; Homerton College, University of Cambridge, Cambridge, UK.
  • Clarke R; Robertson Centre for Biostatistics, Boyd Orr Building, University of Glasgow, Glasgow, UK.
  • Li L; Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  • Rankin N; Biocenter Oulu, Oulu, Finland.
  • Welsh P; Computational Medicine, Faculty of Medicine, University of Oulu, Finland.
  • Delles C; Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Jukema JW; Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Trompet S; Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  • Ford I; Biocenter Oulu, Oulu, Finland.
  • Perola M; Department of Genomics of Complex Diseases, School of Public Health, Imperial College London, UK.
  • Salomaa V; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Järvelin MR; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Chen Z; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Lawlor DA; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Ala-Korpela M; Chinese Academy of Medical Sciences, 9 Dongdan San Tiao, Beijing, China.
  • Danesh J; Department of Global Health, School of Public Health, Peking University, Beijing, China.
  • Davey Smith G; Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
  • Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
  • Butterworth A; Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
  • Würtz P; Leiden University Medical Centre, Leiden, The Netherlands.
Circulation ; 138(22): 2499-2512, 2018 11 27.
Article en En | MEDLINE | ID: mdl-30524137
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Metabolómica / Proproteína Convertasa 9 Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Circulation Año: 2018 Tipo del documento: Article País de afiliación: Finlandia
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Metabolómica / Proproteína Convertasa 9 Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Circulation Año: 2018 Tipo del documento: Article País de afiliación: Finlandia