JAK2 regulation by licochalcone H inhibits the cell growth and induces apoptosis in oral squamous cell carcinoma.

Oh, Ha-Na; Oh, Keon Bong; Lee, Mee-Hyun; Seo, Ji-Hye; Kim, Eunae; Yoon, Goo; Cho, Seung-Sik; Cho, Young Sik; Choi, Hyun Woo; Chae, Jung-Ii; Shim, Jung-Hyun

Oh, Ha-Na; Oh, Keon Bong; Lee, Mee-Hyun; Seo, Ji-Hye; Kim, Eunae; Yoon, Goo; Cho, Seung-Sik; Cho, Young Sik; Choi, Hyun Woo; Chae, Jung-Ii; Shim, Jung-Hyun.

Afiliación

Oh HN; Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.
Oh KB; Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju 55365, Republic of Korea.
Lee MH; The China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, P.R. China.
Seo JH; Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju 54896, Republic of Korea.
Kim E; College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
Yoon G; Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.
Cho SS; Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.
Cho YS; Department of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea.
Choi HW; Department of Animal Science, Chonbuk National University, Jeonju 54896, Republic of Korea.
Chae JI; Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju 54896, Republic of Korea. Electronic address: jichae@jbnu.ac.kr.
Shim JH; Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea; The China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, P.R. China. Electronic address: s1004jh@gmail.com.

Phytomedicine ; 52: 60-69, 2019 Jan.

Article en En | MEDLINE | ID: mdl-30599913

Asunto(s)

Apoptosis/efectos de los fármacos; Carcinoma de Células Escamosas/patología; Chalconas/farmacología; Janus Quinasa 2/metabolismo; Neoplasias de la Boca/patología; Carcinoma de Células Escamosas/tratamiento farmacológico; Caspasas/metabolismo; Ciclo Celular; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Chalconas/química; Ciclina D1/metabolismo; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Inhibidor p27 de las Quinasas Dependientes de la Ciclina/metabolismo; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Simulación del Acoplamiento Molecular; Neoplasias de la Boca/tratamiento farmacológico; Fosforilación/efectos de los fármacos; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Factor de Transcripción STAT3/metabolismo; Transducción de Señal/efectos de los fármacos; Survivin/metabolismo

Palabras clave

7-AAD, 7-Aminoactinomycin D; Abbreviations: OSCC, Oral squamous cell carcinoma; Apaf-1, apoptotic protease activating factor-1; Apoptosis; C-PARP, cleaved Poly (ADP-Ribose) Polymerase; CHOP, CCAAT/enhancer-binding protein homologous protein; DAPI, 4'-6-diamidino-2-phenylindole; DR, Death receptor; FBS, fetal bovine serum; JAK, Janus kinase; JAK2; LC, Licochalcone; Licochalcone H; MMP, Mitochondrial membrane potential; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide; Oral cancer; PBS, phosphate-buffered saline; ROS, Reactive oxygen species; RT, Room temperature; STAT, Signal transducer and activators of transcription; STAT3; TPK, tyrosine protein kinase; cyto C, cytochrome C; tBid, truncated Bid

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Apoptosis / Chalconas / Janus Quinasa 2 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article

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