NLRX1 regulates TNF-&#945;-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells.

Singh, Kritarth; Roy, Milton; Prajapati, Paresh; Lipatova, Anastasia; Sripada, Lakshmi; Gohel, Dhruv; Singh, Aru; Mane, Meenal; Godbole, Madan M; Chumakov, Peter M; Singh, Rajesh

NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells.

Singh, Kritarth; Roy, Milton; Prajapati, Paresh; Lipatova, Anastasia; Sripada, Lakshmi; Gohel, Dhruv; Singh, Aru; Mane, Meenal; Godbole, Madan M; Chumakov, Peter M; Singh, Rajesh.

Afiliación

Singh K; Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India.
Roy M; Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India.
Prajapati P; SCoBIRC Department of Neuroscience, University of Kentucky, 741S.Limestone, BBSRB, Lexington, KY 40536, USA.
Lipatova A; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 119991 Moscow, Russia.
Sripada L; Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India.
Gohel D; Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India.
Singh A; Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
Mane M; Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India.
Godbole MM; Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
Chumakov PM; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, 119991 Moscow, Russia; Chumakov Institute of Poliomyelitis and Viral Encephalitis, Federal Scientific Center on Research and Development of Immunobiology Products, Russian Academy of Sciences, 142782 Moscow, R
Singh R; Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India. Electronic address: rajesh.singh-biochem@msubaroda.ac.

Biochim Biophys Acta Mol Basis Dis ; 1865(6): 1460-1476, 2019 06 01.

Article en En | MEDLINE | ID: mdl-30802640

Asunto(s)

Neoplasias de la Mama/genética; Regulación Neoplásica de la Expresión Génica; Lisosomas/metabolismo; Mitocondrias/metabolismo; Proteínas Mitocondriales/genética; Factor de Necrosis Tumoral alfa/genética; Autofagia/efectos de los fármacos; Autofagia/genética; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Femenino; Células HEK293; Humanos; Metástasis Linfática; Lisosomas/efectos de los fármacos; Células MCF-7; Mitocondrias/efectos de los fármacos; Mitocondrias/patología; Proteínas Mitocondriales/antagonistas & inhibidores; Proteínas Mitocondriales/metabolismo; Mitofagia/efectos de los fármacos; Mitofagia/genética; Invasividad Neoplásica; Fosforilación Oxidativa/efectos de los fármacos; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Transducción de Señal; Microambiente Tumoral/genética; Factor de Necrosis Tumoral alfa/metabolismo; Factor de Necrosis Tumoral alfa/farmacología

Palabras clave

Autophagy; Breast cancer; Inflammation; Lysosomes; Mitochondrial function; NLRX1

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Regulación Neoplásica de la Expresión Génica / Factor de Necrosis Tumoral alfa / Proteínas Mitocondriales / Lisosomas / Mitocondrias Límite: Female / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Año: 2019 Tipo del documento: Article País de afiliación: India

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