Your browser doesn't support javascript.
loading
Pilot Study on the Effect of Orally Administered Bisphenol A on Glucose and Insulin Response in Nonobese Adults.
Hagobian, Todd Alan; Bird, Alyssa; Stanelle, Sean; Williams, Dana; Schaffner, Andrew; Phelan, Suzanne.
Afiliación
  • Hagobian TA; Department of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California.
  • Bird A; Center for Health Research, California Polytechnic State University, San Luis Obispo, California.
  • Stanelle S; Department of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California.
  • Williams D; Department of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California.
  • Schaffner A; Department of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California.
  • Phelan S; Center for Health Research, California Polytechnic State University, San Luis Obispo, California.
J Endocr Soc ; 3(3): 643-654, 2019 Mar 01.
Article en En | MEDLINE | ID: mdl-30842988
OBJECTIVE: To determine the effects of varying doses of orally administered BPA on indices of glucose metabolism. METHODS: Eleven college students (21.0 ± 0.8 years; 24.2 ± 3.9 kg/m2) were randomized in a double-blinded, crossover fashion separated by >1 week to placebo (PL), deuterated BPA at 4 µg/kg body weight (BPA-4), and deuterated BPA at 50 µg/kg body weight (BPA-50). Total BPA, glucose, insulin, and C-peptide were assessed at baseline, minutes 15, 30, 45, 60, and every 30 minutes for 2 hours in response to a glucose tolerance test. RESULTS: There was a significant condition × time interaction for total BPA (P < 0.001) such that BPA increased more rapidly in BPA-50 than BPA-4 and PL (P = 0.003) and increased more rapidly in BPA-4 than PL (P < 0.001). There were no significant condition × time interactions on glucose, insulin, and C-peptide. Significant condition main effects were observed for glucose such that BPA-50 was significantly lower than PL (P = 0.036) and nearly lower for BPA-4 vs PL (P = 0.056). Significant condition main effects were observed such that insulin in BPA-50 was lower than BPA-4 (P = 0.021), and C-peptide in BPA-50 was lower than BPA-4 (t18 = 3.95; Tukey-adjusted P = 0.003). Glucose, insulin, and C-peptide areas under the curve for the 3-hour profile were significantly lower in BPA-50 vs PL (P < 0.05). CONCLUSION: Orally administered BPA protocol appeared feasible and has immediate effects on glucose, insulin, and C-peptide concentrations.
Palabras clave

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: J Endocr Soc Año: 2019 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: J Endocr Soc Año: 2019 Tipo del documento: Article