Salmonella Typhi From Blood Cultures in the Democratic Republic of the Congo: A 10-Year Surveillance.
Clin Infect Dis
; 68(Suppl 2): S130-S137, 2019 03 07.
Article
en En
| MEDLINE
| ID: mdl-30845337
ABSTRACT
BACKGROUND:
This study gives an overview of a decade (2007-2017) of hospital-based Salmonella Typhi bloodstream infection (BSI) surveillance in the Democratic Republic of the Congo (DRC), at 4 main sampling sites.METHODS:
Blood cultures were sampled in hospital-admitted patients with suspected BSI, according to standardized clinical indications. The results of the surveillance period 2015-2017 were compiled with those of previous surveillance periods (2007-2010 and 2011-2014). Whole genome sequencing of isolates with decreased ciprofloxacin susceptibility (DCS) was performed.RESULTS:
Salmonella Typhi was isolated in 1.4% (531/37 388) and 10.3% (531/5177) of suspected and culture-confirmed BSI episodes, respectively. Salmonella Typhi ranked first among the BSI pathogens in adults (n = 220), but was mostly (n = 301 [56.7%]) isolated from children, of which 72.1% (217/301) and 31.6% (95/301) were <10 years and <5 years old, respectively. Multidrug resistance (MDR), DCS, and combined MDR/DCS were found in 38.3% (n = 180), 24.5% (n = 115), and 11.9% (n = 56) of 470 first isolates, respectively. MDR and DCS rates had increased since 2007, but remained stable during 2015-2017 with no geographical clustering at the province level. Most (91/93 [97.8%]) DCS isolates sequenced belonged to Genotyphi genotype 2.5.1, and gyr S83 was the most frequent DCS mutation (76/93 [81.7%]). Infections occurred perennially, but increased during the rainy season.CONCLUSIONS:
Salmonella Typhi was a frequent cause of BSI in adults and children in DRC, with high rates of antibiotic resistance. Sustainable surveillance and implementation of vaccination are compelling.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Salmonella typhi
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Fiebre Tifoidea
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Bacteriemia
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Monitoreo Epidemiológico
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Cultivo de Sangre
Tipo de estudio:
Screening_studies
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Humans
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Infant
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Middle aged
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Newborn
País/Región como asunto:
Africa
Idioma:
En
Revista:
Clin Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2019
Tipo del documento:
Article