A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls.
Behav Neurol
; 2019: 7694503, 2019.
Article
en En
| MEDLINE
| ID: mdl-30891100
ABSTRACT
OBJECTIVE:
To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls.SETTING:
Hospital emergency department.PARTICIPANTS:
21 women ages 18-35 with TBI and 21 controls.DESIGN:
Repeated measures. MAINMEASURES:
Serum samples at baseline and 72 hours; immunoassays for estradiol (E2), progesterone (PRO), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and cortisol (CORT); and health history.RESULTS:
Women with TBI had lower E2 (p = 0.042) and higher CORT (p = 0.028) levels over time. Lower Glasgow Coma Scale (GSC) and OCs were associated with lower FSH (GCS p = 0.021; OCs p = 0.016) and higher CORT (GCS p = 0.001; OCs p = 0.008).CONCLUSION:
Acute TBI may suppress E2 and increase CORT in young women. OCs appeared to independently affect CORT and FSH responses. Future work is needed with a larger sample to characterize TBI effects on women's endogenous hormone response to injury and OC use's effects on post-TBI stress response and gonadal function, as well as secondary injury.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
/
Hormona Luteinizante
/
Factores de Edad
/
Lesiones Traumáticas del Encéfalo
/
Hormona Folículo Estimulante
Límite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Behav Neurol
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos