Inheritance of a Phenotypically Neutral Epimutation Evokes Gene Silencing in Later Generations.

Duempelmann, Lea; Mohn, Fabio; Shimada, Yukiko; Oberti, Daniele; Andriollo, Aude; Lochs, Silke; Bühler, Marc

Duempelmann, Lea; Mohn, Fabio; Shimada, Yukiko; Oberti, Daniele; Andriollo, Aude; Lochs, Silke; Bühler, Marc.

Afiliación

Duempelmann L; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Petersplatz 10, 4003 Basel, Switzerland.
Mohn F; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Shimada Y; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Oberti D; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Andriollo A; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Lochs S; Oncode Institute, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 Utrecht, the Netherlands.
Bühler M; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Petersplatz 10, 4003 Basel, Switzerland. Electronic address: marc.buehler@fmi.ch.

Mol Cell ; 74(3): 534-541.e4, 2019 05 02.

Article en En | MEDLINE | ID: mdl-30898439

Asunto(s)

Silenciador del Gen; Heterocromatina/genética; Histonas/genética; Proteínas Nucleares/genética; Proteínas de Schizosaccharomyces pombe/genética; Proteínas de Ciclo Celular/genética; Epigénesis Genética; N-Metiltransferasa de Histona-Lisina; Metilación; Metiltransferasas/genética; Mutación/genética; Interferencia de ARN; Schizosaccharomyces/genética

Palabras clave

H3K9me3; Paf1C; RNA interference; RNAe; epigenetic memory; heterochromatin; phenotypic plasticity; si3 mark; transcriptional gene silencing; transgenerational inheritance

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Heterocromatina / Histonas / Silenciador del Gen / Proteínas de Schizosaccharomyces pombe Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Suiza

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