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WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan, Edmond M; Shibue, Tsukasa; McFarland, James M; Gaeta, Benjamin; Ghandi, Mahmoud; Dumont, Nancy; Gonzalez, Alfredo; McPartlan, Justine S; Li, Tianxia; Zhang, Yanxi; Bin Liu, Jie; Lazaro, Jean-Bernard; Gu, Peili; Piett, Cortt G; Apffel, Annie; Ali, Syed O; Deasy, Rebecca; Keskula, Paula; Ng, Raymond W S; Roberts, Emma A; Reznichenko, Elizaveta; Leung, Lisa; Alimova, Maria; Schenone, Monica; Islam, Mirazul; Maruvka, Yosef E; Liu, Yang; Roper, Jatin; Raghavan, Srivatsan; Giannakis, Marios; Tseng, Yuen-Yi; Nagel, Zachary D; D'Andrea, Alan; Root, David E; Boehm, Jesse S; Getz, Gad; Chang, Sandy; Golub, Todd R; Tsherniak, Aviad; Vazquez, Francisca; Bass, Adam J.
Afiliación
  • Chan EM; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Shibue T; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • McFarland JM; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Gaeta B; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Ghandi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Dumont N; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Gonzalez A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • McPartlan JS; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Li T; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Zhang Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Bin Liu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Lazaro JB; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Gu P; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Piett CG; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Apffel A; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Ali SO; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Deasy R; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Keskula P; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Ng RWS; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Roberts EA; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Reznichenko E; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Leung L; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Alimova M; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Schenone M; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Islam M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Maruvka YE; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Liu Y; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Roper J; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Giannakis M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Tseng YY; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
  • Nagel ZD; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • D'Andrea A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Root DE; Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC, USA.
  • Boehm JS; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Getz G; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Chang S; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Golub TR; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Tsherniak A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Vazquez F; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Bass AJ; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Nature ; 568(7753): 551-556, 2019 04.
Article en En | MEDLINE | ID: mdl-30971823
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Repeticiones de Microsatélite / Inestabilidad de Microsatélites / Helicasa del Síndrome de Werner / Mutaciones Letales Sintéticas / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Repeticiones de Microsatélite / Inestabilidad de Microsatélites / Helicasa del Síndrome de Werner / Mutaciones Letales Sintéticas / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos