Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients.

Bhuvaneshwar, Krithika; Harris, Michael; Gusev, Yuriy; Madhavan, Subha; Iyer, Ramaswamy; Vilboux, Thierry; Deeken, John; Yang, Elizabeth; Shankar, Sadhna

Bhuvaneshwar, Krithika; Harris, Michael; Gusev, Yuriy; Madhavan, Subha; Iyer, Ramaswamy; Vilboux, Thierry; Deeken, John; Yang, Elizabeth; Shankar, Sadhna.

Afiliación

Bhuvaneshwar K; Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington DC, USA. kb472@georgetown.edu.
Harris M; Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington DC, USA.
Gusev Y; Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington DC, USA.
Madhavan S; Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington DC, USA.
Iyer R; Inova Translational Medicine Institute, Fairfax, VA, USA.
Vilboux T; Inova Translational Medicine Institute, Fairfax, VA, USA.
Deeken J; Inova Translational Medicine Institute, Fairfax, VA, USA.
Yang E; Inova Children's Hospital, Falls Church, VA, USA.
Shankar S; Center for Cancer and Blood Disorders of Northern Virginia, Pediatric Specialists of Virginia, Falls Church, VA, USA.

BMC Cancer ; 19(1): 357, 2019 Apr 16.

Article en En | MEDLINE | ID: mdl-30991985

Asunto(s)

Células Sanguíneas/metabolismo; Neoplasias Óseas/genética; Resistencia a Antineoplásicos/genética; Genómica; Mutación de Línea Germinal; Osteosarcoma/genética; Alelos; Biomarcadores de Tumor; Neoplasias Óseas/mortalidad; Frecuencia de los Genes; Genómica/métodos; Genotipo; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Estimación de Kaplan-Meier; Osteosarcoma/mortalidad; Polimorfismo de Nucleótido Simple; Pronóstico

Palabras clave

Childhood cancers; Drug resistance; Genetics; Osteosarcoma; Pharmacogenomics; Whole genome sequencing

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Sanguíneas / Neoplasias Óseas / Osteosarcoma / Mutación de Línea Germinal / Resistencia a Antineoplásicos / Genómica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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