Dynamic iron status after acute heart failure.
Arch Cardiovasc Dis
; 112(6-7): 410-419, 2019.
Article
en En
| MEDLINE
| ID: mdl-31006624
ABSTRACT
BACKGROUND:
Iron deficiency (ID) is common in heart failure (HF), and is associated with unfavourable clinical outcomes. Although it is recommended to screen for ID in HF, there is no clear consensus on the optimal timing of its assessment.AIM:
To analyse changes in iron status during a short-term follow-up in patients admitted for acute HF.METHODS:
Iron status (serum ferritin concentration and transferrin saturation) was determined in 110 consecutive patients (median age 81 years) admitted to a referral centre for acute HF, at three timepoints (admission, discharge and 1 month after discharge). ID was defined according to the guidelines.RESULTS:
The prevalence rates of ID at admission, discharge and 1 month were, respectively, 75% (95% confidence interval [CI] 67-83%), 61% (95% CI 52-70%), and 70% (95% CI 61-79%) (P=0.008). Changes in prevalence were significant between admission and discharge (P=0.0018). Despite a similar ID prevalence at admission and 1 month (P=0.34), iron status changed in 25% of patients. Between admission and discharge, variation in C-reactive protein correlated significantly with that of ferritin (ρ=0.30; P=0.001). Advanced age, anaemia, low ferritin concentration and low creatinine clearance were associated with the persistence of ID from admission to 1 month.CONCLUSIONS:
Iron status is dynamic in patients admitted for acute HF. Although ID was as frequent at admission as at 1 month after discharge, iron status varied in 25% of patients.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Anemia Ferropénica
/
Insuficiencia Cardíaca
/
Hierro
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Arch Cardiovasc Dis
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2019
Tipo del documento:
Article