Formaldehyde produced from d-ribose under neutral and alkaline conditions.
Toxicol Rep
; 6: 298-304, 2019.
Article
en En
| MEDLINE
| ID: mdl-31008059
Formaldehyde is toxic and has been implicated in the pathologies of various diseases, such as cognitive impairment and cancer. Though d-ribose is widely studied and provided as a supplement to food such as flavor and drinks, no laboratories have reported that d-ribose is involved in the formaldehyde production. Here, we show that formaldehyde is produced from d-ribose in lysine or glycine solution and Tris-HCl buffer under neutral and alkaline conditions. Intraperitoneal injection of C57BL/6J mice with d-ribose significantly increased the concentration of brain formaldehyde, compared to the injection with d-glucose or saline. These data suggest that formaldehyde levels should be monitored for the people who take d-ribose as a supplement.
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MEDLINE
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En
Revista:
Toxicol Rep
Año:
2019
Tipo del documento:
Article
País de afiliación:
China