A case report on metastatic ileal neuroendocrine neoplasm to the breast masquerading as primary breast cancer: A diagnostic challenge and management dilemma.
Medicine (Baltimore)
; 98(16): e14989, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-31008928
ABSTRACT
RATIONALE Metastatic neuroendocrine neoplasms (NENs) to the breast are very rare entities comprising only 1% to 2% of all metastatic breast tumors. In this article, we describe a case of a neuroendocrine ileal neoplasm metastatic to breast and liver, with breast metastatic tumor to be the initial manifestation of the disease. PATIENT CONCERNS We herein report a rare case of a female patient admitted to our department with a palpable painful mass on her left breast. DIAGNOSIS The surgical and histological investigation revealed a metastatic neuroendocrine neoplasm to the breast originated from terminal ileum. INTERVENTIONS:
A left lumpectomy, right hemicolectomy, cholecystectomy, left hepatectomy along with liver metastasectomies (V, VI, VIII) plus radiofrequency ablation of lesions to the right liver lobe plus standard lymphadenectomy was performed.OUTCOMES:
Considering the advanced stage of the disease, the patient received an adjuvant therapy of somatostatin analog plus everolimus. Under the guidance of oncological consultation, patients follow-up with CT and MRI scan and clinical re-evaluations in the first 3 and 6 months, substantiates no evidence of recurrence and she presents herself asymptomatic. LESSONS An appropriate level of suspicion and selective immunohistochemistry in these cases, particularly where no prior history of a known primary neuroendocrine neoplasm occurs, may help to diagnose a previously undetected neuroendocrine tumor elsewhere in the body and provide guidance for the appropriate treatment selection.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
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Tumores Neuroendocrinos
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Neoplasias del Íleon
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Neoplasias Hepáticas
Tipo de estudio:
Diagnostic_studies
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Guideline
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2019
Tipo del documento:
Article
País de afiliación:
Grecia