CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes.

Datsomor, Alex K; Zic, Nikola; Li, Keshuai; Olsen, Rolf E; Jin, Yang; Vik, Jon Olav; Edvardsen, Rolf B; Grammes, Fabian; Wargelius, Anna; Winge, Per

Datsomor, Alex K; Zic, Nikola; Li, Keshuai; Olsen, Rolf E; Jin, Yang; Vik, Jon Olav; Edvardsen, Rolf B; Grammes, Fabian; Wargelius, Anna; Winge, Per.

Afiliación

Datsomor AK; Norwegian University of Science and Technology, Department of Biology, Trondheim, N-7491, Norway.
Zic N; Norwegian University of Science and Technology, Department of Biology, Trondheim, N-7491, Norway.
Li K; Norwegian University of Science and Technology, Department of Biology, Trondheim, N-7491, Norway.
Olsen RE; BioMar AS, Trondheim, Norway.
Jin Y; Norwegian University of Science and Technology, Department of Biology, Trondheim, N-7491, Norway.
Vik JO; Institute of Marine Research, Bergen, N-5817, Norway.
Edvardsen RB; Norwegian University of Life Sciences, Department of Animal and Aquacultural Sciences, N-1432, Ås, Norway.
Grammes F; Norwegian University of Life Sciences, Department of Animal and Aquacultural Sciences, N-1432, Ås, Norway.
Wargelius A; Institute of Marine Research, Bergen, N-5817, Norway.
Winge P; Norwegian University of Life Sciences, Department of Animal and Aquacultural Sciences, N-1432, Ås, Norway.

Sci Rep ; 9(1): 7533, 2019 05 17.

Article en En | MEDLINE | ID: mdl-31101849

Asunto(s)

Elongasas de Ácidos Grasos/genética; Ácido Graso Sintasas/metabolismo; Ácidos Grasos Insaturados/biosíntesis; Salmo salar/genética; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo; Animales; Ácido Araquidónico/biosíntesis; Encéfalo/metabolismo; Sistemas CRISPR-Cas; Ácidos Docosahexaenoicos/biosíntesis; Ácido Eicosapentaenoico/biosíntesis; Elongasas de Ácidos Grasos/metabolismo; Ácidos Grasos Omega-3/metabolismo; Técnicas de Inactivación de Genes; Metabolismo de los Lípidos/genética; Músculos/metabolismo; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/genética

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Salmo salar / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Ácido Graso Sintasas / Ácidos Grasos Insaturados / Elongasas de Ácidos Grasos Límite: Animals Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Noruega

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