Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.

Majumder, Shounak; Taylor, William R; Yab, Tracy C; Berger, Calise K; Dukek, Brian A; Cao, Xiaoming; Foote, Patrick H; Wu, Chung Wah; Mahoney, Douglas W; Aslanian, Harry R; Fernández-Del Castillo, Carlos; Doyle, Leona A; Farrell, James J; Fisher, William E; Lee, Linda S; Lee, Yvonne N; Park, Walter; Rodrigues, Clifton; Gould Rothberg, Bonnie Elyssa; Salem, Ronald R; Simeone, Diane M; Urs, Sumithra; Van Buren, George; Smyrk, Thomas C; Allawi, Hatim T; Lidgard, Graham P; Raimondo, Massimo; Chari, Suresh T; Kendrick, Michael L; Kisiel, John B; Topazian, Mark D; Ahlquist, David A

Majumder, Shounak; Taylor, William R; Yab, Tracy C; Berger, Calise K; Dukek, Brian A; Cao, Xiaoming; Foote, Patrick H; Wu, Chung Wah; Mahoney, Douglas W; Aslanian, Harry R; Fernández-Del Castillo, Carlos; Doyle, Leona A; Farrell, James J; Fisher, William E; Lee, Linda S; Lee, Yvonne N; Park, Walter; Rodrigues, Clifton; Gould Rothberg, Bonnie Elyssa; Salem, Ronald R; Simeone, Diane M; Urs, Sumithra; Van Buren, George; Smyrk, Thomas C; Allawi, Hatim T; Lidgard, Graham P; Raimondo, Massimo; Chari, Suresh T; Kendrick, Michael L; Kisiel, John B; Topazian, Mark D; Ahlquist, David A.

Afiliación

Majumder S; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Taylor WR; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Yab TC; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Berger CK; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Dukek BA; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Cao X; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Foote PH; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Wu CW; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Mahoney DW; Department of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Aslanian HR; Yale University, New Haven, Connecticut, USA.
Fernández-Del Castillo C; Massachusetts General Hospital, Boston, Massachusetts, USA.
Doyle LA; Brigham and Women's Hospital, Boston, Massachusetts, USA.
Farrell JJ; Yale University, New Haven, Connecticut, USA.
Fisher WE; Baylor College of Medicine, Houston, Texas, USA.
Lee LS; Brigham and Women's Hospital, Boston, Massachusetts, USA.
Lee YN; Stanford Heath Care, Palo Alto, California, USA.
Park W; Stanford Heath Care, Palo Alto, California, USA.
Rodrigues C; Massachusetts General Hospital, Boston, Massachusetts, USA.
Gould Rothberg BE; Yale University, New Haven, Connecticut, USA.
Salem RR; Yale University, New Haven, Connecticut, USA.
Simeone DM; University of Michigan, Ann Arbor, Michigan, USA.
Urs S; University of Michigan, Ann Arbor, Michigan, USA.
Van Buren G; Baylor College of Medicine, Houston, Texas, USA.
Smyrk TC; Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Allawi HT; Exact Sciences Corporation, Madison, Wisconsin, USA.
Lidgard GP; Exact Sciences Corporation, Madison, Wisconsin, USA.
Raimondo M; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Chari ST; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Kendrick ML; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Kisiel JB; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Topazian MD; Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Ahlquist DA; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL.

Am J Gastroenterol ; 114(9): 1539-1549, 2019 09.

Article en En | MEDLINE | ID: mdl-31306149

Asunto(s)

Carcinoma Ductal Pancreático/genética; Cistadenoma Seroso/genética; Metilación de ADN/genética; Quiste Pancreático/genética; Neoplasias Intraductales Pancreáticas/genética; Neoplasias Pancreáticas/genética; Lesiones Precancerosas/genética; Anciano; Proteína Morfogenética Ósea 3/genética; Antígeno Carcinoembrionario/metabolismo; Carcinoma Ductal Pancreático/diagnóstico; Carcinoma Ductal Pancreático/patología; Líquido Quístico/metabolismo; Cistadenoma Seroso/diagnóstico; Cistadenoma Seroso/patología; Femenino; Humanos; Masculino; Persona de Mediana Edad; Clasificación del Tumor; Quiste Pancreático/diagnóstico; Quiste Pancreático/patología; Neoplasias Intraductales Pancreáticas/diagnóstico; Neoplasias Intraductales Pancreáticas/patología; Neoplasias Pancreáticas/diagnóstico; Neoplasias Pancreáticas/patología; Reacción en Cadena de la Polimerasa; Lesiones Precancerosas/diagnóstico; Lesiones Precancerosas/patología; Proteínas Proto-Oncogénicas p21(ras)/genética; Reproducibilidad de los Resultados; Sensibilidad y Especificidad; Proteínas de Dominio T Box/genética

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Quiste Pancreático / Neoplasias Pancreáticas / Lesiones Precancerosas / Cistadenoma Seroso / Metilación de ADN / Carcinoma Ductal Pancreático / Neoplasias Intraductales Pancreáticas Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Gastroenterol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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