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Pharmacological antagonism of histamine H2R ameliorated L-DOPA-induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD.
Ahmed, Mohamed Rafiuddin; Jayakumar, Mithya; Ahmed, Mohamed Sohail; Zamaleeva, Alsu I; Tao, Juan; Li, Eric Howard; Job, Judith K; Pittenger, Christopher; Ohtsu, Hiroshi; Rajadas, Jayakumar.
Afiliación
  • Ahmed MR; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Jayakumar M; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Ahmed MS; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Zamaleeva AI; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Tao J; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Li EH; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Job JK; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Pittenger C; Department of Psychiatry, Child Study Center, and Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA.
  • Ohtsu H; Graduate School of Engineering, Applied Quantum Medical Engineering, Tohoku University, Sendai, Miyagi, Japan.
  • Rajadas J; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco. Electronic address: jayraja@stanford.edu.
Neurobiol Aging ; 81: 177-189, 2019 09.
Article en En | MEDLINE | ID: mdl-31306812
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Ranitidina / Levodopa / Proteínas Proto-Oncogénicas c-fos / Discinesia Inducida por Medicamentos / Quinasa 3 del Receptor Acoplado a Proteína-G / Antagonistas de los Receptores H2 de la Histamina Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Ranitidina / Levodopa / Proteínas Proto-Oncogénicas c-fos / Discinesia Inducida por Medicamentos / Quinasa 3 del Receptor Acoplado a Proteína-G / Antagonistas de los Receptores H2 de la Histamina Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos