Genetic deletion of Ca<sub>v</sub>3.2 T-type calcium channels abolishes H<sub>2</sub>S-dependent somatic and visceral pain signaling in C57BL/6 mice.

Matsui, Kazuki; Tsubota, Maho; Fukushi, Saaya; Koike, Nene; Masuda, Hiroshi; Kasanami, Yoshihito; Miyazaki, Takaya; Sekiguchi, Fumiko; Ohkubo, Tsuyako; Yoshida, Shigeru; Mukai, Yutaro; Oita, Akira; Takada, Mitsutaka; Kawabata, Atsufumi

Genetic deletion of Ca_v3.2 T-type calcium channels abolishes H₂S-dependent somatic and visceral pain signaling in C57BL/6 mice.

Matsui, Kazuki; Tsubota, Maho; Fukushi, Saaya; Koike, Nene; Masuda, Hiroshi; Kasanami, Yoshihito; Miyazaki, Takaya; Sekiguchi, Fumiko; Ohkubo, Tsuyako; Yoshida, Shigeru; Mukai, Yutaro; Oita, Akira; Takada, Mitsutaka; Kawabata, Atsufumi.

Afiliación

Matsui K; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan; Department of Pharmacy, National Cerebral and Cardiovascular Center, Suita, 565-8565, Japan.
Tsubota M; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Fukushi S; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Koike N; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Masuda H; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Kasanami Y; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Miyazaki T; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Sekiguchi F; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Ohkubo T; Division of Basic Medical Sciences and Fundamental Nursing, Faculty of Nursing, Fukuoka Nursing College, Fukuoka, 814-0193, Japan.
Yoshida S; Department of Life Science, Faculty of Science and Engineering, Kindai University, Higashi-Osaka, 577-8502, Japan.
Mukai Y; Department of Pharmacy, National Cerebral and Cardiovascular Center, Suita, 565-8565, Japan.
Oita A; Department of Pharmacy, National Cerebral and Cardiovascular Center, Suita, 565-8565, Japan.
Takada M; Division of Clinical Drug Informatics, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan.
Kawabata A; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, 577-8502, Japan. Electronic address: kawabata@phar.kindai.ac.jp.

J Pharmacol Sci ; 140(3): 310-312, 2019 Jul.

Article en En | MEDLINE | ID: mdl-31492577

Asunto(s)

Canales de Calcio Tipo T/genética; Canales de Calcio Tipo T/metabolismo; Sulfuro de Hidrógeno/farmacología; Dolor Nociceptivo/metabolismo; Transducción de Señal/efectos de los fármacos; Dolor Visceral/metabolismo; Animales; Calcio/metabolismo; Bloqueadores de los Canales de Calcio/farmacología; Línea Celular; Células HEK293; Humanos; Ratones; Ratones Endogámicos C57BL; Ratas; Ratas Wistar; Canal Catiónico TRPA1/metabolismo

Palabras clave

Ca(v)3.2 T-type calcium channel; Hydrogen sulfide; Pain

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transducción de Señal / Canales de Calcio Tipo T / Dolor Nociceptivo / Dolor Visceral / Sulfuro de Hidrógeno Límite: Animals / Humans Idioma: En Revista: J Pharmacol Sci Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón

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