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Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019.
Roberts, David J; Davis, Grahame S; Cole, Michelle J; Naik, Dixita; Maru, Hitiksha; Woodford, Neil; Muir, Peter; Horner, Paddy; Simms, Ian; Thickett, George; Crook, Paul; Foster, Kirsty; Andrews, Nick; Saunders, John; Fifer, Helen; Folkard, Kate; Gill, O Noel.
Afiliación
  • Roberts DJ; National Infection Service, Public Health England, London, United Kingdom.
  • Davis GS; National Infection Service, Public Health England, London, United Kingdom.
  • Cole MJ; National Infection Service, Public Health England, London, United Kingdom.
  • Naik D; National Infection Service, Public Health England, London, United Kingdom.
  • Maru H; National Infection Service, Public Health England, London, United Kingdom.
  • Woodford N; National Infection Service, Public Health England, London, United Kingdom.
  • Muir P; South West Regional Public Health Laboratory, Public Health England, Bristol, United Kingdom.
  • Horner P; Population Health Sciences, University of Bristol, Bristol, United Kingdom.
  • Simms I; National Infection Service, Public Health England, London, United Kingdom.
  • Thickett G; National Infection Service, Public Health England, London, United Kingdom.
  • Crook P; Field Service South East and London, Public Health England, London, United Kingdom.
  • Foster K; Public Health England North East Centre, Newcastle-upon-Tyne, United Kingdom.
  • Andrews N; Statistics, Modelling and Economics Department, Public Health England, London, United Kingdom.
  • Saunders J; National Infection Service, Public Health England, London, United Kingdom.
  • Fifer H; National Infection Service, Public Health England, London, United Kingdom.
  • Folkard K; National Infection Service, Public Health England, London, United Kingdom.
  • Gill ON; National Infection Service, Public Health England, London, United Kingdom.
Euro Surveill ; 24(38)2019 Sep.
Article en En | MEDLINE | ID: mdl-31552817
ABSTRACT
We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Variación Genética / Infecciones por Chlamydia / Chlamydia trachomatis / Tamizaje Masivo / Técnicas de Amplificación de Ácido Nucleico Tipo de estudio: Diagnostic_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Euro Surveill Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Variación Genética / Infecciones por Chlamydia / Chlamydia trachomatis / Tamizaje Masivo / Técnicas de Amplificación de Ácido Nucleico Tipo de estudio: Diagnostic_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Euro Surveill Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido