Role of pentraxin-3 in risk assessment of patients with metabolic syndrome.
Physiol Int
; 106(3): 283-293, 2019 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-31560233
ABSTRACT
BACKGROUND:
Inflammation plays a major role in the development of metabolic syndrome (MetS) and its progression. Recent studies have shown that pentraxin-3 (PTX-3), osteoprogerin (OPG), and tumor necrosis factor-alpha (TNF-α) are key factors in MetS pathophysiology, but evidence for endorsing their clinical use is currently unclear and insufficient.AIM:
The study aimed to evaluate the association between the inflammatory biomarkers' levels and the severity of MetS.METHODS:
The study was observational, transversal, prospective, cohort, and analytical type. We enrolled 80 patients (MF = 1, mean age = 55 ± 10.77 years) who met MetS criteria. The study protocol included medical history, physical examination, 6-min walk test distance (6MWTD), biochemical tests, electrocardiogram, echocardiography, and carotid ultrasonography. We also performed plasmatic measurement of PTX-3, OPG, and TNF-α, in addition to standard biochemical tests.RESULTS:
Subjects with severe MetS had higher values of body mass index (BMI) and waist circumference (p < 0.001, p = 0.001). PTX-3 levels were significantly higher in patients with severe MetS (p = 0.03) and the values were not influenced by age or gender. OPG positively correlated with BMI (r = 0.264, p = 0.018). 6MWTD was lower in patients with severe MetS (p = 0.005), whereas CCA-IMT was higher in this group of patients (p = 0.005). In addition, the receiver operating characteristic (ROC) curve analysis for PTX-3 identified a cut-off value of 10.7 ng/dl that differentiates between mild and severe MetS [AUC 0.656; sensitivity =47.1% (95% CI = 36.1%-62.3%); specificity = 78.9% (95% CI = 54.4%-93.9%)].CONCLUSION:
PTX-3 was correlated with the severity of MetS, with other inflammatory parameters and cardiovascular tests. CCA-IMT and 6MWTD are useful in differentiating between mild and severe MetS.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteína C-Reactiva
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Componente Amiloide P Sérico
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Síndrome Metabólico
Tipo de estudio:
Etiology_studies
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Guideline
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Physiol Int
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rumanía