Adverse Health Outcomes Associated With Fetal Alcohol Exposure: A Systematic Review Focused on Cardio-Renal Outcomes.
J Stud Alcohol Drugs
; 80(5): 515-523, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31603752
ABSTRACT
OBJECTIVE:
The purpose of this study was to undertake a comprehensive review to identify all the available preclinical and clinical literature investigating cardiovascular and renal outcomes in offspring with prenatal alcohol exposure (PAE).METHOD:
We used a systematic review methodology to survey published clinical and preclinical studies investigating cardio-renal outcomes in offspring with PAE. Literature was systematically searched across four electronic databases and titles/abstracts screened against specific inclusion/exclusion criteria.RESULTS:
A total of 22 studies (9 clinical and 13 preclinical) were included. It was found that PAE can affect aspects of cardiovascular and renal function, including blood pressure, heart rate control, heart function, and urinary excretion. However, there remain very few clinical studies in this area, and those contained in this review were typically of poor quality and/or had small sample sizes.CONCLUSIONS:
Despite the limited research and variable findings across studies, current studies provide preliminary evidence of cardio-renal dysfunction in offspring with PAE.
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Base de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Consumo de Bebidas Alcohólicas
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Stud Alcohol Drugs
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2019
Tipo del documento:
Article
País de afiliación:
Australia