Murine cytomegalovirus disseminates independently of CX3CR1, CCL2 or its m131/m129 chemokine homologue.
J Gen Virol
; 100(12): 1695-1700, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31609196
ABSTRACT
Cytomegaloviruses (CMVs) use myeloid cells to move within their hosts. Murine CMV (MCMV) colonizes the salivary glands for long-term shedding, and reaches them via CD11c+ infected cells. A need to recruit patrolling monocytes for systemic spread has been proposed, based on poor salivary gland infection in fractalkine receptor (CX3CR1)-deficient mice. We found no significant CX3CR1 dependence of salivary gland infection. CCL2 and the viral m131/m129 chemokine homologue were also redundant for acute MCMV spread, arguing against a need for inflammation or infection to recruit additional monocytes to the entry site. M131/m129 promoted salivary gland infection, but only after the initial seeding of infected cells to this site. Our data support the idea that MCMV disseminates by infecting and mobilizing tissue-resident dendritic cells.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas Virales
/
Muromegalovirus
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Infecciones por Herpesviridae
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Quimiocina CCL2
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Quimiocinas CC
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Interacciones Huésped-Patógeno
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Receptor 1 de Quimiocinas CX3C
Límite:
Animals
Idioma:
En
Revista:
J Gen Virol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Australia