Tissue-specific FAH deficiency alters sleep-wake patterns and results in chronic tyrosinemia in mice.

Yang, Shuzhang; Siepka, Sandra M; Cox, Kimberly H; Kumar, Vivek; de Groot, Marleen; Chelliah, Yogarany; Chen, Jun; Tu, Benjamin; Takahashi, Joseph S

Yang, Shuzhang; Siepka, Sandra M; Cox, Kimberly H; Kumar, Vivek; de Groot, Marleen; Chelliah, Yogarany; Chen, Jun; Tu, Benjamin; Takahashi, Joseph S.

Afiliación

Yang S; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.
Siepka SM; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.
Cox KH; Department of Neurobiology, Northwestern University, Evanston, IL 60208.
Kumar V; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.
de Groot M; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.
Chelliah Y; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.
Chen J; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.
Tu B; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.
Takahashi JS; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111.

Proc Natl Acad Sci U S A ; 116(44): 22229-22236, 2019 10 29.

Article en En | MEDLINE | ID: mdl-31611405

Asunto(s)

Ritmo Circadiano; Hidrolasas/genética; Mutación; Sueño; Tirosinemias/genética; 4-Hidroxifenilpiruvato Dioxigenasa/antagonistas & inhibidores; Animales; Células Cultivadas; Ciclohexanonas/uso terapéutico; Inhibidores Enzimáticos/uso terapéutico; Estabilidad de Enzimas; Células HEK293; Homocigoto; Humanos; Hidrolasas/deficiencia; Hidrolasas/metabolismo; Riñón/metabolismo; Hígado/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Nitrobenzoatos/uso terapéutico; Especificidad de Órganos; Núcleo Supraquiasmático/metabolismo; Tirosinemias/tratamiento farmacológico; Tirosinemias/fisiopatología

Palabras clave

ENU mutagenesis; sleep; tyrosinemia

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sueño / Ritmo Circadiano / Tirosinemias / Hidrolasas / Mutación Límite: Animals / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article

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