Neuroprotective triterpene saponins from the leaves of Panax notoginseng.
Nat Prod Res
; 35(14): 2388-2394, 2021 Jul.
Article
en En
| MEDLINE
| ID: mdl-31638430
ABSTRACT
Two new triterpene saponins, namely notoginsenoside Ng5 (1) and notoginsenoside Ng6 (2) were isolated from the leaves of Panax notoginseng, along with five known ones. Their structures were determined by chemical methods, NMR and X-ray experiments. The absolute configuration of compound 3 with four sugar units was confirmed by single crystal X-ray analysis. Compounds 2-4 and 6 inhibited PC12 cell damage induced by serum deprivation, and increased cell viability from 58.7 ± 6.7% to 66.7 ± 4.5%, 76.1 ± 6.1%, 64.7 ± 5.2% and 67.2 ± 5.0% at 10 µM, respectively.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Saponinas
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Triterpenos
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Hojas de la Planta
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Fármacos Neuroprotectores
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Panax notoginseng
Límite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Año:
2021
Tipo del documento:
Article
País de afiliación:
China