Your browser doesn't support javascript.
loading
Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.
Audemard-Verger, Alexandra; Gasnault, Jacques; Faisant, Maxime; Besse, Marie-Catherine; Martin-Silva, Nicolas; Berra, Mado; Fournier, Luc; Boutemy, Jonathan; Maigne, Gwenola; De Boysson, Hubert; Ruet, Alexis; Vabret, Astrid; Chapon, Françoise; Martin-Blondel, Guillaume; Aouba, Achille.
Afiliación
  • Audemard-Verger A; Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
  • Gasnault J; Normandy University, Caen, France.
  • Faisant M; Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
  • Besse MC; Department of Internal Medicine and Clinical Immunology, Unit of Neuroviral Diseases, CHU de Bicetre, Le Kremlin-Bicetre, France.
  • Martin-Silva N; Department of Pathology, CHU de Caen, Caen, France.
  • Berra M; Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
  • Fournier L; Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
  • Boutemy J; Department of Neurology, CHU de Caen, Caen, France.
  • Maigne G; Department of Radiology, CHU de Caen, Caen, France.
  • De Boysson H; Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
  • Ruet A; Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
  • Vabret A; Department of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
  • Chapon F; Department of Physical and Rehabilitation Medicine, CHU de Caen, Caen, France.
  • Martin-Blondel G; Department of Virology, CHU de Caen, Caen, France.
  • Aouba A; Department of Pathology, CHU de Caen, Caen, France.
Open Forum Infect Dis ; 6(10): ofz374, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31660340
ABSTRACT
In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2019 Tipo del documento: Article País de afiliación: Francia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2019 Tipo del documento: Article País de afiliación: Francia