Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.
Open Forum Infect Dis
; 6(10): ofz374, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31660340
ABSTRACT
In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Open Forum Infect Dis
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia