Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.
Eur J Med Chem
; 186: 111893, 2020 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-31761383
ABSTRACT
The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Antiinflamatorios no Esteroideos
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Pirazolonas
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Antiinfecciosos
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Neoplasias
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Antineoplásicos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Eur J Med Chem
Año:
2020
Tipo del documento:
Article
País de afiliación:
China