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Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.
Zhao, Zefeng; Dai, Xufen; Li, Chenyang; Wang, Xiao; Tian, Jiale; Feng, Ying; Xie, Jing; Ma, Cong; Nie, Zhuang; Fan, Peinan; Qian, Mingcheng; He, Xirui; Wu, Shaoping; Zhang, Yongmin; Zheng, Xiaohui.
Afiliación
  • Zhao Z; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Dai X; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Li C; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Wang X; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Tian J; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Feng Y; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Xie J; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Ma C; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Nie Z; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Fan P; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
  • Qian M; Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, 213164, Jiangsu, China; Laboratory for Medicinal Chemistry, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.
  • He X; Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China.
  • Wu S; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China. Electronic address: wushaoping@nwu.edu.cn.
  • Zhang Y; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China; Sorbonne Université, Institut Parisien de Chimie Moléculaire, CNRS UMR 8232,
  • Zheng X; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an, 710069, China.
Eur J Med Chem ; 186: 111893, 2020 Jan 15.
Article en En | MEDLINE | ID: mdl-31761383
ABSTRACT
The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Pirazolonas / Antiinfecciosos / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Pirazolonas / Antiinfecciosos / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: China