The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2RÎ³ânull Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab.

Jodeleit, Henrika; Caesar, Janina; Villarroel Aguilera, Christina; Sterz, Sebastian; Holdt, Lesca; Beigel, Florian; Stallhofer, Johannes; Breiteneicher, Simone; Bartnik, Eckart; Siebeck, Matthias; Gropp, Roswitha

The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2RÎ³ânull Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab.

Jodeleit, Henrika; Caesar, Janina; Villarroel Aguilera, Christina; Sterz, Sebastian; Holdt, Lesca; Beigel, Florian; Stallhofer, Johannes; Breiteneicher, Simone; Bartnik, Eckart; Siebeck, Matthias; Gropp, Roswitha.

Afiliación

Jodeleit H; Department of General, Visceral und Transplantation Surgery, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Caesar J; Department of General, Visceral und Transplantation Surgery, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Villarroel Aguilera C; Department of General, Visceral und Transplantation Surgery, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Sterz S; Institute of Laboratory Medicine, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Holdt L; Institute of Laboratory Medicine, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Beigel F; Department of Medicine II, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Stallhofer J; Department of Medicine II, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Breiteneicher S; Department of Medicine II, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Bartnik E; Immunology and Inflammation Research TA, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany.
Siebeck M; Department of General, Visceral und Transplantation Surgery, Hospital of the Ludwig Maximilian University of Munich, München, Germany.
Gropp R; Department of General, Visceral und Transplantation Surgery, Hospital of the Ludwig Maximilian University of Munich, München, Germany.

Inflamm Bowel Dis ; 26(4): 557-569, 2020 03 04.

Article en En | MEDLINE | ID: mdl-31782956

Asunto(s)

Adalimumab/farmacología; Colitis Ulcerosa/sangre; Colitis Ulcerosa/patología; Leucocitos Mononucleares/metabolismo; Adalimumab/uso terapéutico; Adulto; Anciano; Animales; Colitis Ulcerosa/tratamiento farmacológico; Colitis Ulcerosa/metabolismo; Colon/patología; Modelos Animales de Enfermedad; Femenino; Humanos; Inflamación/patología; Leucocitos Mononucleares/efectos de los fármacos; Leucocitos Mononucleares/inmunología; Estudios Longitudinales; Masculino; Ratones; Ratones Endogámicos NOD; Ratones SCID; Persona de Mediana Edad; Monocitos/efectos de los fármacos; Monocitos/metabolismo; Bazo/patología; Linfocitos T Colaboradores-Inductores/efectos de los fármacos; Linfocitos T Colaboradores-Inductores/inmunología; Linfocitos T Colaboradores-Inductores/metabolismo; Adulto Joven

Palabras clave

NOD/scid IL-2RÎ³ânull; NSG-UC; adalimumab; immunological profiling; inflammatory bowel disease; ulcerative colitis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Colitis Ulcerosa / Adalimumab Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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