[Investigation of the importance of zinc-signaling: insights from animal model study and human disease].
Nihon Yakurigaku Zasshi
; 154(6): 327-334, 2019.
Article
en Ja
| MEDLINE
| ID: mdl-31787685
ABSTRACT
Zinc (Zn) is one of the essential trace elements required for human developments and it plays an important role in the maintenance of numerous tissue homeostasis. The amount of Zn levels was below the constant level which induced the various harmful health effects such as impaired growth, hair loss, taste disturbance, anorexia. Maintenance of Zn homeostasis in body mainly depends on two families of Zn transporters; Zrt- and Irt-like proteins (ZIPs), and Zinc transporters (ZnTs). Some studies based on the gene knock-out mice and human genetic analysis have been reported the relationship between zinc transporters and human diseases. Recent studies have shown that Zn transporter-mediated Zn ion behaves as a signaling factor, called Zn signal, that exerts a multiple function in cellular events. In this review article we describe important physiological roles of Zn transporters and their contribution at the molecular, biochemical, and genetic levels underlying the mechanisms of human diseases.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Zinc
/
Transducción de Señal
/
Proteínas de Transporte de Catión
/
Homeostasis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
Ja
Revista:
Nihon Yakurigaku Zasshi
Año:
2019
Tipo del documento:
Article