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Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
McDonald, Ian M; Grant, Gavin D; East, Michael P; Gilbert, Thomas S K; Wilkerson, Emily M; Goldfarb, Dennis; Beri, Joshua; Herring, Laura E; Vaziri, Cyrus; Cook, Jeanette Gowen; Emanuele, Michael J; Graves, Lee M.
Afiliación
  • McDonald IM; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Grant GD; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599.
  • East MP; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Gilbert TSK; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Michael Hooker Proteomics Core Facility, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Wilkerson EM; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Michael Hooker Proteomics Core Facility, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Goldfarb D; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110; Institute for Informatics, Washington University School of Medicine, St. Louis, Missouri 63110.
  • Beri J; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Michael Hooker Proteomics Core Facility, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Herring LE; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Michael Hooker Proteomics Core Facility, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Vaziri C; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Cook JG; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Emanuele MJ; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Graves LM; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Michael Hooker Proteomics Core Facility, University of North Carolina, Chapel Hill, North Carolina
J Biol Chem ; 295(8): 2359-2374, 2020 02 21.
Article en En | MEDLINE | ID: mdl-31896573
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Espectrometría de Masas / Proteínas Serina-Treonina Quinasas / Inhibidores de Proteínas Quinasas / Mitosis Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Espectrometría de Masas / Proteínas Serina-Treonina Quinasas / Inhibidores de Proteínas Quinasas / Mitosis Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article