Study on strontium doped tricalcium silicate synthesized through sol-gel process.
Mater Sci Eng C Mater Biol Appl
; 108: 110431, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31923972
ABSTRACT
We successfully synthesized a strontium-doped tricalcium silicate (SrxCa3-xSiO5, Srâ¯=â¯0 to 2â¯mol%) bone cement using the sol-gel process. The material properties including crystallinity, setting time, mechanical strength, and hydration products were characterized. Release of ions and pH values of simulated body fluid soaked with the bone cement were measured. In vitro biocompatibility of different concentrations of the material was evaluated by the viability of L929 cells. The setting times of as-prepared slurries were all <70â¯min. Doping with 0.5â¯mol% Sr reduced the final setting time by 20â¯min. After 14â¯days curing, 0.25â¯mol% Sr-doped SrxCa3-xSiO5 possessed the highest compressive strength of 45â¯MPa among all the Sr-doped groups with no statistical difference to Ca3SiO5. The bioactivity of the materials was confirmed with the formation of an apatite layer on the surface of the materials after immersion in simulated body fluid. In addition, the proliferation of L929 cells exposed to 1â¯mol% Sr was significantly promoted as compared to no Sr doping. SrxCa3-xSiO5 is a novel and advanced material that has the potential to serve as a bone cement in bone restoration with appropriate mechanical strength and favorable biocompatibility.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Estroncio
/
Cementos para Huesos
/
Ensayo de Materiales
/
Silicatos
/
Compuestos de Calcio
/
Proliferación Celular
Límite:
Animals
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Año:
2020
Tipo del documento:
Article
País de afiliación:
Taiwán