[Pathological and protective effects of tumor necrosis factor-alpha in multiple sclerosis]. / Patologicheskie i protektivnye éffekty faktora nekroza opukholi-al'fa pri rasseiannom skleroze.
Zh Nevrol Psikhiatr Im S S Korsakova
; 119(10. Vyp. 2): 14-20, 2019.
Article
en Ru
| MEDLINE
| ID: mdl-31934984
ABSTRACT
The immunomodulatory cytokine tumor necrosis factor-alpha (TNF-α) is involved in the regulation of both physiological and pathological processes in the central nervous system (CNS). The effects of TNF-α on CNS reported in clinical trials and experimental studies, evidence of involvement of this cytokine in the pathogenesis of multiple sclerosis are analyzed. Possible causes of failures of non-selective pharmacological inhibition of TNF-α effects in MS are considered in view of current concepts on mechanisms of TNF-α action.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Factor de Necrosis Tumoral alfa
/
Factores Protectores
/
Esclerosis Múltiple
Límite:
Humans
Idioma:
Ru
Revista:
Zh Nevrol Psikhiatr Im S S Korsakova
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia