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Disruption of a RAC1-centred network is associated with Alzheimer's disease pathology and causes age-dependent neurodegeneration.
Kikuchi, Masataka; Sekiya, Michiko; Hara, Norikazu; Miyashita, Akinori; Kuwano, Ryozo; Ikeuchi, Takeshi; Iijima, Koichi M; Nakaya, Akihiro.
Afiliación
  • Kikuchi M; Department of Genome Informatics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
  • Sekiya M; Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan.
  • Hara N; Department of Experimental Gerontology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi 467-8603, Japan.
  • Miyashita A; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Kuwano R; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Iijima KM; Asahigawaso Medical-Welfare Center, Asahigawaso Research Institute, Okayama 703-8207, Japan.
  • Nakaya A; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Hum Mol Genet ; 29(5): 817-833, 2020 03 27.
Article en En | MEDLINE | ID: mdl-31942999
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Ovillos Neurofibrilares / Enfermedades Neurodegenerativas / Proteína de Unión al GTP rac1 / Redes Reguladoras de Genes / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Ovillos Neurofibrilares / Enfermedades Neurodegenerativas / Proteína de Unión al GTP rac1 / Redes Reguladoras de Genes / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2020 Tipo del documento: Article País de afiliación: Japón