2-NBDG, 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxyglucose; ABCG2, ATP-binding cassette subfamily G member 2; ACN, acetonitrile; Au/Uv, absorbance unit of ultraviolet-visible spectroscopy; BCRP, breast cancer resistant protein; BERA, bioengineered miRNA agent; Bioengineered RNA; CI, combination index; CPT, cisplatin; Cancer; Chemosensitivity; DOX, doxorubicin; E. coli, Escherichia coli; ESI, electrospray ionization; FPLC, fast protein liquid chromatography; Fa, fraction affected; GLUT1; GLUT1, glucose transporter protein type 1; HCC, hepatocellular carcinoma; HPLC, high-performance liquid chromatography; IS, internal standard; KRB, Krebs­Ringer bicarbonate; LAT1; LAT1, large neutral amino acid transporter 1; LC­MS/MS, liquid chromatography­tandem mass spectroscopy; MCT4, monocarboxylate transporter 4; MRE, miRNA response elements; MRM, multiple reaction monitoring; MiR-328; OS, osteosarcoma; PAGE, polyacrylamide gel electrophoresis; PTEN, phosphatase and tensin homolog; PVDF, Polyvinylidene fluoride; RAGE, receptor for advanced glycosylation end products; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; SLC2A1, 7A5, 16A3, solute carrier family 2 member 1, family 7 member 5, family 16 member 3; WT, wild type; hBERA, humanized bioengineered miRNA agent; hsa, Homo sapiens; htRNASer, human seryl-tRNA; mTOR, mammalian target of rapamycin; miR or miRNA, microRNA; ncRNA, noncoding RNAs; nt, nucleotide