Clones assemble! The clonal complexity of blood during ontogeny and disease.
Exp Hematol
; 83: 35-47, 2020 03.
Article
en En
| MEDLINE
| ID: mdl-32006606
ABSTRACT
Hematopoietic stem and progenitor cells (HSPCs) govern the daily expansion and turnover of billions of specialized blood cells. Given their clinical utility, much effort has been made toward understanding the dynamics of hematopoietic production from this pool of stem cells. An understanding of hematopoietic stem cell clonal dynamics during blood ontogeny could yield important insights into hematopoietic regulation, especially during aging and repeated exposure to hematopoietic stress-insults that may predispose individuals to the development of hematopoietic disease. Here, we review the current state of research regarding the clonal complexity of the hematopoietic system during embryogenesis, adulthood, and hematologic disease.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
/
Células Madre Hematopoyéticas
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Enfermedades Hematológicas
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Hematopoyesis
Límite:
Adult
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Humans
Idioma:
En
Revista:
Exp Hematol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Túnez