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SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications.
Singh, Shalini; Ahmed, Doaa; Dolatshad, Hamid; Tatwavedi, Dharamveer; Schulze, Ulrike; Sanchi, Andrea; Ryley, Sarah; Dhir, Ashish; Carpenter, Lee; Watt, Suzanne M; Roberts, David J; Abdel-Aal, Amal M; Sayed, Sohair K; Mohamed, Somaia A; Schuh, Anna; Vyas, Paresh; Killick, Sally; Kotini, Andriana G; Papapetrou, Eirini P; Wiseman, Daniel H; Pellagatti, Andrea; Boultwood, Jacqueline.
Afiliación
  • Singh S; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Ahmed D; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Dolatshad H; Clinical Pathology Department, Assiut University, Assiut, Egypt.
  • Tatwavedi D; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Schulze U; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Sanchi A; Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Ryley S; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Dhir A; Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, The Churchill Hospital, Oxford, UK.
  • Carpenter L; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Watt SM; Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Roberts DJ; Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Abdel-Aal AM; National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK.
  • Sayed SK; Clinical Pathology Department, Assiut University, Assiut, Egypt.
  • Mohamed SA; Clinical Pathology Department, Assiut University, Assiut, Egypt.
  • Schuh A; Clinical Pathology Department, Assiut University, Assiut, Egypt.
  • Vyas P; Molecular Diagnostic Centre, Department of Oncology, University of Oxford, Oxford, UK.
  • Killick S; MRC Molecular Hematology Unit, WIMM, University of Oxford, Oxford, UK.
  • Kotini AG; Haematology Theme Oxford Biomedical Research Centre and Department of Hematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Papapetrou EP; Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
  • Wiseman DH; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Pellagatti A; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Boultwood J; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Leukemia ; 34(9): 2525-2530, 2020 09.
Article en En | MEDLINE | ID: mdl-32076118
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Síndromes Mielodisplásicos / Daño del ADN / Factores de Empalme de ARN / Estructuras R-Loop / Mutación Límite: Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Síndromes Mielodisplásicos / Daño del ADN / Factores de Empalme de ARN / Estructuras R-Loop / Mutación Límite: Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido