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Bioactive flavonoid dimers from Chinese dragon's blood, the red resin of Dracaena cochinchinensis.
Lang, Guang-Zhen; Li, Chuang-Jun; Gaohu, Tong-Yue; Li, Chuan; Ma, Jie; Yang, Jing-Zhi; Zhou, Tian-Tian; Yuan, Yu-He; Ye, Fei; Wei, Jian-He; Zhang, Dong-Ming.
Afiliación
  • Lang GZ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Li CJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: lichuangjun@imm.ac.cn.
  • Gaohu TY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Li C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Ma J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Yang JZ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Zhou TT; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Yuan YH; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Ye F; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Wei JH; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, People's Republic of China.
  • Zhang DM; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: zhangdm@imm.ac.cn.
Bioorg Chem ; 97: 103659, 2020 04.
Article en En | MEDLINE | ID: mdl-32078940
ABSTRACT
Seven flavonoid dimers, biflavocochins A-G, together with six known compounds were isolated from the red resins of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were elucidated based on extensive spectroscopic analysis. The absolute configurations of 1-7 was assigned by experimental and quantum chemical calculated ECD spectra, and that of 4 was further established by X-ray diffraction analysis using Cu Kα radiation. Compounds 1-3 are novel dimers of homoisoflavonoid and dihydrochalcone with a unique dibenzopyran ring. Compounds 2, 6, 7 exhibited moderate PTP1B inhibitory activities in an enzyme assay. Compound 1 showed neuroprotective effect on serum deficiency-induced cellular damage in PC12 cells.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Flavonoides / Extractos Vegetales / Fármacos Neuroprotectores / Dracaena / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Flavonoides / Extractos Vegetales / Fármacos Neuroprotectores / Dracaena / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article