The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.

Sugawara, Sho; Kanamaru, Yusuke; Sekine, Shiori; Maekawa, Lila; Takahashi, Akinori; Yamamoto, Tadashi; Watanabe, Kengo; Fujisawa, Takao; Hattori, Kazuki; Ichijo, Hidenori

Sugawara, Sho; Kanamaru, Yusuke; Sekine, Shiori; Maekawa, Lila; Takahashi, Akinori; Yamamoto, Tadashi; Watanabe, Kengo; Fujisawa, Takao; Hattori, Kazuki; Ichijo, Hidenori.

Afiliación

Sugawara S; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Kanamaru Y; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Sekine S; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Maekawa L; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Takahashi A; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna, Okinawa 904-0495, Japan.
Yamamoto T; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna, Okinawa 904-0495, Japan; Laboratory for Immunogenetics, Center for Integrative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan.
Watanabe K; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Fujisawa T; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Hattori K; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: kzkhattori@13.alumni.u-tokyo.ac.jp.
Ichijo H; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: ichijo@mol.f.u-tokyo.ac.jp.

J Biol Chem ; 295(17): 5588-5601, 2020 04 24.

Article en En | MEDLINE | ID: mdl-32144202

Asunto(s)

Adipocitos Marrones/metabolismo; Regulación hacia Abajo; Metabolismo Energético; Proteínas Mitocondriales/metabolismo; Fosfoproteínas Fosfatasas/metabolismo; Proteína Desacopladora 1/genética; Animales; Células Cultivadas; Células HeLa; Humanos; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Proteínas Mitocondriales/genética; Consumo de Oxígeno; Fosfoproteínas Fosfatasas/genética; Proteína Desacopladora 1/metabolismo

Palabras clave

PGAM family member 5 mitochondrial serine/threonine protein phosphatase (PGAM5); adipocyte; brown adipocyte; brown adipose tissue; energy metabolism; intramembrane proteolysis; lipid metabolism; mitochondria; mitochondrial homeostasis; obesity; phosphatidylserine decarboxylase (PISD); protein phosphatase; uncoupling protein 1 (UCP1)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Fosfoproteínas Fosfatasas / Proteínas Mitocondriales / Metabolismo Energético / Adipocitos Marrones / Proteína Desacopladora 1 Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Japón

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