NK cells mediate clearance of CD8<sup>+</sup> T cell-resistant tumors in response to STING agonists.

Nicolai, Christopher J; Wolf, Natalie; Chang, I-Chang; Kirn, Georgia; Marcus, Assaf; Ndubaku, Chudi O; McWhirter, Sarah M; Raulet, David H

NK cells mediate clearance of CD8⁺ T cell-resistant tumors in response to STING agonists.

Nicolai, Christopher J; Wolf, Natalie; Chang, I-Chang; Kirn, Georgia; Marcus, Assaf; Ndubaku, Chudi O; McWhirter, Sarah M; Raulet, David H.

Afiliación

Nicolai CJ; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Wolf N; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Chang IC; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kirn G; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Marcus A; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Ndubaku CO; Aduro Biotech Inc., Berkeley, CA 94710, USA.
McWhirter SM; Aduro Biotech Inc., Berkeley, CA 94710, USA.
Raulet DH; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. raulet@berkeley.edu.

Sci Immunol ; 5(45)2020 03 20.

Article en En | MEDLINE | ID: mdl-32198222

Asunto(s)

Linfocitos T CD8-positivos/efectos de los fármacos; Linfocitos T CD8-positivos/inmunología; Células Asesinas Naturales/inmunología; Proteínas de la Membrana/agonistas; Neoplasias/tratamiento farmacológico; Neoplasias/inmunología; Animales; Sistemas CRISPR-Cas/efectos de los fármacos; Sistemas CRISPR-Cas/inmunología; Interferón Tipo I/farmacología; Células Asesinas Naturales/efectos de los fármacos; Proteínas de la Membrana/inmunología; Ratones; Ratones Congénicos; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL; Ratones Noqueados; Neoplasias/patología; Células Tumorales Cultivadas

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Linfocitos T CD8-positivos / Proteínas de la Membrana / Neoplasias Límite: Animals Idioma: En Revista: Sci Immunol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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