Structures of Human Transglutaminase 2: Finding Clues for Interference in Cross-linking Mediated Activity.
Int J Mol Sci
; 21(6)2020 Mar 23.
Article
en En
| MEDLINE
| ID: mdl-32210142
ABSTRACT
Human transglutaminase 2 (TGase2) has various functions, including roles in various cellular processes such as apoptosis, development, differentiation, wound healing, and angiogenesis, and is linked to many diseases such as cancer. Although TGase2 has been considered an optimized drug target for the treatment of cancer, fibrosis, and neurodegenerative disorders, it has been difficult to generate TGase2-targeted drugs for clinical use because of the relatively flat and broad active site on TGase2. To design more specific and powerful inhibitors, detailed structural information about TGase2 complexed with various effector and inhibitor molecules is required. In this review, we summarized the current structural studies on TGase2, which will aid in designing drugs that can overcome the aforementioned limitations.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Conformación Proteica
/
Modelos Moleculares
/
Transglutaminasas
/
Proteínas de Unión al GTP
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2020
Tipo del documento:
Article