Growth arrest specific protein 7 inhibits tau fibrillogenesis.
Biochem Biophys Res Commun
; 526(2): 281-286, 2020 05 28.
Article
en En
| MEDLINE
| ID: mdl-32216967
ABSTRACT
Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core element of tau oligomerization and the C-terminal domain of tau and alters the conformation not to form fibrils. These results suggest that Gas7 may serve to protect against Alzheimer's disease and other tauopathies by preventing tau fibrillogenesis.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas tau
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Agregación Patológica de Proteínas
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Agregado de Proteínas
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Proteínas del Tejido Nervioso
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón