Resistance to carbapenems and other antibiotics in Klebsiella pneumoniae found in seals indicates anthropogenic pollution.
Vet Rec
; 187(4): 154, 2020 Aug 22.
Article
en En
| MEDLINE
| ID: mdl-32327551
ABSTRACT
BACKGROUND:
The beta-lactamase enzyme OXA-48 has spread widely in recent years in Enterobacteriaceae associated with man, disseminated primarily on incompatibility group L/M plasmids. OXA-48 confers resistance to carbapenems, important antimicrobials for treating highly resistant bacterial infections in humans. This enzyme has rarely been detected in bacteria from animals. Furthermore, the use of carbapenem compounds is not permitted in food-producing animals in Europe and to our knowledge has not been reported in food-producing animals globally.METHODS:
Bacterial isolates from lesions in stranded, free-living, juvenile common seals (Phoca vitulina) were identified. Antimicrobial susceptibility testing and whole genome sequencing analysis were used to characterise antimicrobial resistance genes carried by the bacteria.RESULTS:
Here, we report the detection of Klebsiella pneumoniae subspecies pneumoniae carrying the bla OXA-48 gene on an incompatibility group L/M plasmid from an infection in a common seal.CONCLUSION:
Evidence is accruing that marine mammals may be infected with bacteria originating from anthropogenic sources, such as human sewage, contaminating the environment.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Contaminación del Agua
/
Carbapenémicos
/
Farmacorresistencia Bacteriana
/
Phocidae
/
Klebsiella pneumoniae
Límite:
Animals
País/Región como asunto:
Europa
Idioma:
En
Revista:
Vet Rec
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido