Complete and on-time routine childhood immunisation: determinants and association with severe morbidity in urban informal settlements, Nairobi, Kenya.
Ann Hum Biol
; 47(2): 132-141, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-32429760
ABSTRACT
Background:
Completion of the full series of childhood vaccines on-time is crucial to ensuring greater protection against vaccine-preventable diseases.Aim:
To examine determinants of complete and on-time vaccination and evaluate the relationship between vaccination patterns and severe morbidity outcomes.Subjects andmethods:
Vaccination information from infants in Nairobi Urban Health and Demographic Surveillance System was used to evaluate full and on-time vaccination coverage of routine immunisation. Logistic regression was used to identify determinants of full and on-time vaccination coverage. Cox regression model was used to evaluate the relationship between vaccination status and subsequent severe morbidity. A shared frailty cox model was fitted to account for the heterogeneity in hospitalisation episodes.Results:
Maternal age, post-natal care, parity, ethnicity, and residence place were identified as determinants of vaccination completion. Institutional deliveries and residence place were identified as the determinants of on-time vaccination. A significant 58% (confidence interval [CI] 15-79%) (p = .017) lower mortality was observed among fully immunised children compared with not fully immunised. Lower mortality was observed among on-time immunised children, 64% (CI 20-84%) compared to those with delays.Conclusions:
Improving vaccination timeliness and completion schedule is critical for protection against vaccine preventable diseases and may potentially provide protection beyond these targets.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Morbilidad
/
Vacunación
/
Salud del Lactante
Límite:
Humans
/
Infant
País/Región como asunto:
Africa
Idioma:
En
Revista:
Ann Hum Biol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Kenia