Resistance to the "last resort" antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes.
Chem Commun (Camb)
; 56(50): 6874-6877, 2020 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-32432618
ABSTRACT
MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the "last-resort" antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono- rather than multinuclear member of the alkaline phosphatase superfamily.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Zinc
/
Colistina
/
Farmacorresistencia Bacteriana
/
Fosfatasa Alcalina
/
Antibacterianos
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido