In-Vitro-Generated Hypertrophic-Like Adipocytes Displaying <i>PPARG</i> Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo.

Aprile, Marianna; Cataldi, Simona; Perfetto, Caterina; Ambrosio, Maria Rosaria; Italiani, Paola; Tatè, Rosarita; Blüher, Matthias; Ciccodicola, Alfredo; Costa, Valerio

In-Vitro-Generated Hypertrophic-Like Adipocytes Displaying PPARG Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo.

Aprile, Marianna; Cataldi, Simona; Perfetto, Caterina; Ambrosio, Maria Rosaria; Italiani, Paola; Tatè, Rosarita; Blüher, Matthias; Ciccodicola, Alfredo; Costa, Valerio.

Afiliación

Aprile M; Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Via P. Castellino 111, 80131 Naples, Italy.
Cataldi S; Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Via P. Castellino 111, 80131 Naples, Italy.
Perfetto C; Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Via P. Castellino 111, 80131 Naples, Italy.
Ambrosio MR; Department of Translational Medicine, University of Naples "Federico II" & URT "Genomic of Diabetes," Institute of Experimental Endocrinology and Oncology "G. Salvatore," CNR, Via Pansini 5, 80131 Naples, Italy.
Italiani P; Institute of Biochemistry and Cell Biology CNR, Via P. Castellino 111, 80131 Naples, Italy.
Tatè R; Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Via P. Castellino 111, 80131 Naples, Italy.
Blüher M; Department of Medicine, University of Leipzig, 4289 Leipzig, Germany.
Ciccodicola A; Institute of Genetics and Biophysics "Adriano Buzzati-Traverso," CNR, Via P. Castellino 111, 80131 Naples, Italy.
Costa V; Department of Science and Technology, University of Naples "Parthenope," 80131 Naples, Italy.

Cells ; 9(5)2020 05 21.

Article en En | MEDLINE | ID: mdl-32455814

Asunto(s)

Adipocitos/metabolismo; Adipocitos/patología; PPAR gamma/metabolismo; Adipocitos/ultraestructura; Tejido Adiposo/patología; Diferenciación Celular; Línea Celular; Forma de la Célula; Tamaño de la Célula; Femenino; Transportador de Glucosa de Tipo 4/metabolismo; Humanos; Hipertrofia; Gotas Lipídicas/metabolismo; Masculino; Células Madre Mesenquimatosas/metabolismo; Persona de Mediana Edad; Modelos Biológicos; Obesidad/metabolismo; Obesidad/patología; Isoformas de Proteínas/metabolismo

Palabras clave

PPARG isoforms; PPARG splicing; adipogenesis; dominant-negative isoform; hypertrophic adipocytes; hypertrophic obesity; in vitro adipocytes; insulin-resistance

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Adipocitos / PPAR gamma Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Cells Año: 2020 Tipo del documento: Article País de afiliación: Italia

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