A simple score to predict early death after kidney transplantation.
Eur J Clin Invest
; 50(11): e13312, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32533894
ABSTRACT
BACKGROUND:
Few studies have focused on risk stratification for premature death after transplantation. However, stratification of individual risk is an essential step in personalized care. MATERIAL ANDMETHODS:
We have developed a risk score of early post-transplant death (ORLY score) in a prospective multicentre cohort including 942 patients and validated our model in a retrospective independent replication cohort including 874 patients.RESULTS:
60 patients (6.4%) from the prospective cohort died during the first three-year post-transplant. Age, male gender, diabetes, dialysis duration and chronic respiratory failure were associated with early post-transplant death. The multivariable model exhibited good discrimination ability (C-index = 0.78, 95%CI [0.75-0.81]). ORLY score highly predicted early death after transplantation (1.34; 95%CI, 1.22 to 1.48 for each increase of 1 point in score; P < .001). The predictive value of the score in the validation cohort was close to that observed in the experimental cohort (1.41; 95%CI, 1.27 to 1.56 for each increase of 1 point in score; P < .001). Merging the two cohorts, four categories of risk could be individualized low, 0-5 (n = 522, mean risk, 1%); intermediate, 6-7 (n = 739, mean risk 4.7%); moderate, 8-10 (n = 429, mean risk 10%); and high risk 11-15 (n = 132, mean risk 19%).CONCLUSIONS:
The ORLY score discriminates patients with high risk of early death.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Insuficiencia Respiratoria
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Diálisis Renal
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Trasplante de Riñón
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Diabetes Mellitus
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Mortalidad Prematura
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Fallo Renal Crónico
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Clin Invest
Año:
2020
Tipo del documento:
Article
País de afiliación:
Francia