Equine Aging and the Oocyte: A Potential Model for Reproductive Aging in Women.
J Equine Vet Sci
; 89: 103022, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32563447
ABSTRACT
Numerous similarities in reproductive aging have been documented between the mare and woman. Aging is associated with a decline in fertility. In mares and women, oocyte transfer procedures were initially used to establish that oocyte donor age is associated with oocyte quality. Age-associated differences in oocytes include altered morphology, gene expression, and developmental potential. Reactive oxygen species and mitochondrial dysfunction are thought to be important contributors to loss of oocyte quality. In the woman, aneuploidy is a primary consideration with maternal aging. Although misalignment of chromosomes during meiosis has been observed in the mare, less is known in this area. Reproductive aging will be reviewed in the mare and compared with the woman with emphasis on factors that affect oocyte quality and developmental potential. Areas in which the mare could be used as a research model to study reproductive aging in women will be highlighted.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Oocitos
/
Reproducción
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Equine Vet Sci
Año:
2020
Tipo del documento:
Article