LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons.

Zhou, Jing-Jing; Luo, Yi; Chen, Shao-Rui; Shao, Jian-Ying; Sah, Rajan; Pan, Hui-Lin

Zhou, Jing-Jing; Luo, Yi; Chen, Shao-Rui; Shao, Jian-Ying; Sah, Rajan; Pan, Hui-Lin.

Afiliación

Zhou JJ; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Luo Y; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Chen SR; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shao JY; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sah R; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Pan HL; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: huilinpan@mdanderson.org.

Exp Neurol ; 332: 113391, 2020 10.

Article en En | MEDLINE | ID: mdl-32598930

Asunto(s)

Ácido Glutámico/metabolismo; Hipocampo/patología; Canales Iónicos/metabolismo; Accidente Cerebrovascular Isquémico/genética; Proteínas de la Membrana/genética; Neuronas/patología; Animales; Conducta Animal; Región CA1 Hipocampal/patología; Potenciales Postsinápticos Excitadores; Glucosa/deficiencia; Hipoxia/patología; Infarto de la Arteria Cerebral Media/patología; Accidente Cerebrovascular Isquémico/patología; Accidente Cerebrovascular Isquémico/psicología; Proteínas de la Membrana/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Nestina/genética; Técnicas de Placa-Clamp

Palabras clave

Electrophysiology; Excitotoxicity; Ion channel; NMDA receptor; Presynaptic; Reperfusion; SWELL1 channel; Synaptic plasticity

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ácido Glutámico / Accidente Cerebrovascular Isquémico / Hipocampo / Canales Iónicos / Proteínas de la Membrana / Neuronas Límite: Animals Idioma: En Revista: Exp Neurol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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