Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility.

Wang, Hai-Qiao; Gong, Xiao-Mei; Lan, Fen; Zhang, Yi-Han; Xia, Jin-Er; Zhang, Hai; Guo, Jia-Lin; Liu, Min

Wang, Hai-Qiao; Gong, Xiao-Mei; Lan, Fen; Zhang, Yi-Han; Xia, Jin-Er; Zhang, Hai; Guo, Jia-Lin; Liu, Min.

Afiliación

Wang HQ; Department of Traditional Chinese Medicine, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201112, China.
Gong XM; Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Lan F; Department of Pharmacy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Zhang YH; Department of Pharmacy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Xia JE; Department of Pharmacy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Zhang H; Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Guo JL; Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Liu M; Department of Pharmacy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

Curr Pharm Biotechnol ; 22(5): 672-681, 2021.

Article en En | MEDLINE | ID: mdl-32634081

Asunto(s)

Antineoplásicos Fitogénicos/farmacocinética; Saponinas/farmacocinética; Esteroides/farmacocinética; Administración Intravenosa; Administración Oral; Anemarrhena/química; Animales; Antineoplásicos Fitogénicos/química; Disponibilidad Biológica; Biofarmacia; Células CACO-2; Cromatografía Líquida de Alta Presión; Humanos; Técnicas In Vitro; Masculino; Microsomas Hepáticos/metabolismo; Ratas; Ratas Sprague-Dawley; Saponinas/química; Solubilidad; Esteroides/química; Espectrometría de Masas en Tándem

Palabras clave

Caco-2 cells; HPLC-MS/MS; Timosaponin AIII; absorption; bioavailability; biopharmaceutics; liver microsomes.; metabolism; pharmacokinetics

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Saponinas / Esteroides / Antineoplásicos Fitogénicos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Curr Pharm Biotechnol Asunto de la revista: BIOTECNOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China

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