Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent.

Min, Zhenli; Zhu, Yue; Hong, Xing; Yu, Zhijun; Ye, Min; Yuan, Qiong; Hu, Xiamin

Min, Zhenli; Zhu, Yue; Hong, Xing; Yu, Zhijun; Ye, Min; Yuan, Qiong; Hu, Xiamin.

Afiliación

Min Z; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430081, People's Republic of China.
Zhu Y; New Medicine Innovation and Development Institute, College of Medicine, Wuhan University of Science and Technology, Wuhan 430081, People's Republic of China.
Hong X; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430081, People's Republic of China.
Yu Z; Stem Cell Lab, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, People's Republic of China.
Ye M; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430081, People's Republic of China.
Yuan Q; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430081, People's Republic of China.
Hu X; New Medicine Innovation and Development Institute, College of Medicine, Wuhan University of Science and Technology, Wuhan 430081, People's Republic of China.

Drug Des Devel Ther ; 14: 2517-2534, 2020.

Article en En | MEDLINE | ID: mdl-32636614

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Neoplasias del Colon/tratamiento farmacológico; Curcumina/farmacología; Pirazoles/farmacología; Antineoplásicos Fitogénicos/síntesis química; Antineoplásicos Fitogénicos/química; Apoptosis/efectos de los fármacos; Puntos de Control del Ciclo Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Células Cultivadas; Neoplasias del Colon/metabolismo; Neoplasias del Colon/patología; Curcumina/síntesis química; Curcumina/química; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Estructura Molecular; Pirazoles/química; Relación Estructura-Actividad

Palabras clave

1, 5-diheteroarylpenta-1, 4-dien-3-one; ATM gene; cell apoptosis; cell proliferation; colon cancer

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Neoplasias del Colon / Curcumina / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Drug Des Devel Ther Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2020 Tipo del documento: Article

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